- Rapidly (usually 50% decline in GFR within 3 months), with formation of crescents in at least 50% of glomeruli in adequate renal biopsy. Formation of > 80% crescents is asscoiated with poor response to treatment and usually is irreversible.
- RPGN may be due to:
1. Immune-complex mediated diseases (e.g. MPGN)
2. Pauci-immine (e.g. ANCA mediated vasculitis)
3. Anti-GBM (e.g. Goodpastur disease)
- The manifestations of RPGN can vary from asymptomatic proteinuria and hematuria, or increased serum creatinine, to life-threatening renal failure or hypertensive crisis.
- Three histological variants have been identified:
1. Cellualr type
2. Fibrocellular type
3. Fibrous type
N.B. touch sides of the adjacent pictute to see more pictures