Focal Segmental Glomerulosclerosis (FSGS)

- FSGS is a clinicopathological entity with poor prognosis. There is evidence of genetic factors in the pathogenesis of FSGS. Hemodynamic factors have also been implicated.

- The histological features of FSGS do not allow differentiating the primary forms from the secondary ones. 

- Five histological variants have been identified: 
  1. FSGS not otherwise specified (NOS), the most common
  2. Perihilar varian, the lesios are located at the vascular pole
  3. Cellular variant, podoyte hyperplasia & endocapillary hypercellularity
  4. Tip variant, the most benign form  
  5. Collapsing variant, (collapsing glomerulopathy)


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