- FSGS is a clinicopathological entity with poor prognosis. There is evidence of genetic factors in the pathogenesis of FSGS. Hemodynamic factors have also been implicated.
- The histological features of FSGS do not allow differentiating the primary forms from the secondary ones.
- Five histological variants have been identified:
1. FSGS not otherwise specified (NOS), the most common
2. Perihilar varian, the lesios are located at the vascular pole
3. Cellular variant, podoyte hyperplasia & endocapillary hypercellularity
4. Tip variant, the most benign form
5. Collapsing variant, (collapsing glomerulopathy)
N.B. touch sides of the adjacent pictute to see more pictures