Minimal Change Disease (MCD- MCGN)

- The most common pathology encountered in childhood idiopathic nephrotic syndrome

- The glomeruli appear normal in L/M. NIL disease is the pathological entity of MCGN (= Nothing In Light microscopy)

- Effecement of epithelial foot processes is found in MCD by E/M, but this effecement is not characteristic to MCD as it is present in other proteinuric disorders as FSGS, membranous nephropathy and IgA nephropathy. Effacement of epithelial foot processes results in breakdown of podocyte cytoskeleton and proteinuria. Degree of proteinuria is not related to effacement found in epithelial foot processes

N.B. touch sides of the adjacent pictute to see more pictures

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